cees dekker - An Overview
cees dekker - An Overview
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‘Sure, that may be about correct. I try to find a physical comprehension of Organic techniques in a very base-up way. I believe you could possibly distinguish a few lines of investigation in my team in the mean time. The 1st concerns chromosome construction: How will you receive a metre-lengthy DNA polymer folded and organised in this type of microscopic cell? We now have made visualisation methods that enable us to review how, such as, SMC proteins loop DNA (video on Youtube) as a way to Make up chromosomes.
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Round the identical time, the team of Paul McEuen, who was then based mostly on the University of California, Berkeley, confirmed comparable success on ropes of bundled nanotubes. Depending upon the wrapping angle, nanotubes can are available in metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard University independently verified employing scanning tunnelling spectroscopy experiments.
Non-equilibrium folding of unique DNA molecules recaptured nearly a thousand periods in a very good point out nanopore
This yielded a breakthrough. Inside of only some months, we had been able to measure transportation by means of somebody solitary-walled carbon nanotube. Dependant on minimal-temperature experiments by a superb PhD pupil in my team, Sander Tans (now a valued colleague and professor at Delft University of Know-how with the Lively study lab at AMOLF in Amsterdam), we showed that carbon nanotubes ended up real quantum wires with pretty lengthy (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.
Cornelis (Cees) Dekker (Haren, seven april 1959) is een Nederlandse natuurkundige en universiteitshoogleraar verbonden aan de Technische Universiteit Delft. Van 2010 tot en fulfilled 2018 was hij tevens directeur van het Kavli Institute of Nanoscience in Delft. Zijn vakgebied is de moleculaire biofysica; hierbij beweegt hij zich op het grensvlak van de natuurkunde en de biologie waarbij hij gebruikmaakt van de zogeheten nanotechnologie, de technieken om aan enkele atomen en moleculen te kunnen meten.
We condition microbes into varieties that deviate from their pure phenotype. Exclusively, I will display our ability to shape Are living E. coli microbes into novel designs including rectangles, squares, triangles and circles.
Nanopores stand for an elegant and versatile Instrument to measure single molecules. We research novel detection modes with strong-state nanopores as well as various methods to measure proteins with nanopores. Projects encompass the subsequent:
Being familiar with essential procedures regulating the spatial and dynamic organisation of your DNA in live cells.
one). The current–voltage curves confirmed significant modulations with gate voltage, even at place temperature, which was in line with band bending inside of a ~0.6 eV bandgap semiconducting nanotube. These facts also showed the conductance could be modulated by six orders of magnitude by switching the gate voltage. The outcome of the operate — a home-temperature transistor made out of only one carbon nanotube molecule — have been posted in Nature in May well 1998.
Tests pseudotopological and nontopological designs for SMC-pushed DNA loop extrusion against roadblock-traversal experiments
Numerous new phenomena were being uncovered, ceesdekker and he and his study team set up a number one placement in this subject of study. Dekker and his investigate group found out new physics of nanotubes and also explored the feasibility of molecular electronics. In 1998, they were the 1st to construct a transistor dependant on just one nanotube molecule.
2005, discovery in the system of DNA uncoiling by topoisomerase enzymes; discovery of extended-vary conformational adjustments in Mre11/DNA maintenance complexes; and very first pressure measurements on a DNA molecule in the nanopore
The biophysicist from Delft – who has long been Among the most cited researchers while in the Netherlands For a long time – usually takes his obligation to add into the rationalization and popularisation of his operate on the border of physics and biology incredibly seriously and regularly seems while in the media; if not to talk about his do the job, then about the relationship amongst science and his Christian faith.